Thursday, April 19, 2012
Wednesday, April 18, 2012
Dance
Tango
may target deficits associated with Parkinson's disease more
than waltz/foxtrot, but both dances may benefit balance and locomotion.
Pasted
from <http://www.ncbi.nlm.nih.gov/pubmed/19479161>
Glutamate transmission blockade
They
support the hypothesis that blockade of glutamate transmission may have a place
in the management of disabling dyskinesias in Parkinson's disease.
Pasted
from <http://www.ncbi.nlm.nih.gov/pubmed/21371994>
Melatonin
Melatonin-treated
animals perform better in the motor tasks and had no dyskinetic
alterations
Pasted
from <http://www.ncbi.nlm.nih.gov/pubmed/22462019>
Melatonin
is a useful treatment to
delay the cellular and behavioral alterations observed in Parkinson's disease.
Pasted
from <http://www.ncbi.nlm.nih.gov/pubmed/22462019>
Co Q 10
Neuroprotective
Toxicity is not
usually observed with high doses of CoQ10. A daily dosage up to 3600 mg was found to be
tolerated by healthy as well as unhealthy persons.[20] However, some adverse
effects, largely gastrointestinal, are reported with very high intakes. The
observed safe level (OSL) risk assessment method indicated that the evidence of
safety is strong at intakes up to 1200 mg/day, and this level is identified
as the OSL.
Pasted
from <http://en.wikipedia.org/wiki/Coenzyme_Q10>
Thus, CoQ10 functions in every cell of the body to
synthesize energy.
Pasted
from <http://en.wikipedia.org/wiki/Coenzyme_Q10>
Antioxidant function of CoQ10
Pasted
from <http://en.wikipedia.org/wiki/Coenzyme_Q10>
A 2002
study in 80 Parkinson's disease patients found 1200 mg/day reduced the progression by 44%.[74][75] A
phase III trial of 1200 mg/d and 2400 mg/d ran until August 2011.
This study was terminated and the summary concluded: "The investigational
drug is unlikely to demonstrate efficacy over placebo for this indication.
However, no safety issues were discovered."[76]
Pasted
from <http://en.wikipedia.org/wiki/Coenzyme_Q10>
Non-steroidal anti-inflammatory drugs
Not acetaminophen or
aspirin
Maybe ibuprofen and
naproxen
15% reduction of
incidence of development
Velvet Beans
11:52 AM
Mucuna (Mucuna Pruriens), also known as velvet
bean and cowitch, is
an herb used as a minor food crop and medicinal bean in India, West Africa, and
Central America. It is indigenous to India and is a popular medicinal in that
region. It is widespread over most of the subcontinent and can be found in
bushes, hedges and dry-deciduous.
Mucuna can be a very beneficial supplement for
bodybuilders. It
is high in the amino acid L-Dopa which helps maintain healthy cholesterol and
blood sugar levels.
Another benefit of Mucuna, is that it may
increase the production of
HGH (Human Growth Hormone). An increase in HGH levels can increase the body's
ability to build lean muscle and break down fat.
Mucuna has also been shown to have diuretic
effects. It
increases tissue resiliency and improves coordination. Mucuna can also increase
testosterone levels, which in turn can lead to increased muscle mass and
strength.
This
additional finding of a neurorestorative benefit byMucuna pruriens cotyledon powder on the
degenerating dopaminergic neurons in the substantia nigra may be due to
increased complex-I activity and the presence of NADH and coenzyme Q-10.
Pasted
from <http://www.ncbi.nlm.nih.gov/pubmed/15478206>
Anticholinergic
Akineton
Artane
Cogentin
Kemadrin
Trihexyphenidyl
Benztropnie
Atropine
Dry mouth
Blurred vision
Confusion
Constipation
Trouble urinating
Hallucinations
Trouble sleeping
Blocks ACh
May relieve shaking
and stiffness and improve muscle control
Amantadine
Symmetrel
Maybe
anticholinergic
May facilitate
dopamine release
Skin rash
Ankle swelling
Leg discoloration
Confusion
Depression
Dizziness
hallucinations
May relieve symptoms
by increasing the amount of dopamine in the brain
MAO-B Inhibitors
- More adverse effects than levodopa
Dizziness
Headache
Nausea
Confusion
Mood changes
Trouble sleeping
Prevents mao-b from
destroying dopamine
May slow neuronal
degeneration
May delay disease
progress
Eldepryl
Selegiline
Rasagiline
Slower
progression of disease
neuroprotective
COMT Inhibitors
Entacapone
Saves
L-dopa from metabolism
(no
signifcant alteration of liver function)
Tolcapone
|
|
Prolong levodopa
|
|
|
(with liver
damage)
|
Makes more levodopa
available to enter brain and relieve symptoms
Used along with
levodopa
Vivid dreams
Sleep disturbances
Hallucinations
Nausea
Diarrhea
Involuntary
movements
Urine discoloration
Changes in liver
enzymes
Comtan
Tasmar
Dopamine Agonists
Mirapex
Requip
Parlodel
Permax
Cabergoline
valvulopathy
Pramipexole
Ropinirole
Pergolide
valvulopathy
Bromocriptine
Piribedil
Rotigotine, lisuride
Initial
stages,
Skin
patches
Rotigotine
for restless leg syndrome
Apomorphine
Common
hallucinations, common
Act on dopamine
receptors
Lower rate of motor
fluctuations
In severe tremors
Less effective
For initial years
Minimal dose - delay
motor complications
Neuroprotective?
Impulse control
disorders
Nausea
Hallucinations
Insomnia
Drowsiness
Constipation
Vomiting
Dizziness
Fainting
Confusion
sleepiness
Levodopa
Sinemet
Sinemet CR
Converts to dopamine
Dyskinesis
(constipation
Nausea
Vomiting
Hallucinations
Confusion
Dizziness)
Low protein diet
medopar
Parkinson's Disease
Levodopa
Levodopa with
Carbidopa
Co-careldopa
Co-beneldopa
Entacapone
Dopamine agonists,
MAO-B inhibitors
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