COMT Inhibitors

Entacapone

Saves L-dopa from metabolism

(no signifcant alteration of liver function)

Tolcapone

	Prolong levodopa
	(with liver damage)

Makes more levodopa available to enter brain and relieve symptoms

Used along with levodopa

Vivid dreams

Sleep disturbances

Hallucinations

Nausea

Diarrhea

Involuntary movements

Urine discoloration

Changes in liver enzymes

Comtan

Tasmar