Wednesday, April 18, 2012

Co Q 10


Neuroprotective


Toxicity is not usually observed with high doses of CoQ10. A daily dosage up to 3600 mg was found to be tolerated by healthy as well as unhealthy persons.[20] However, some adverse effects, largely gastrointestinal, are reported with very high intakes. The observed safe level (OSL) risk assessment method indicated that the evidence of safety is strong at intakes up to 1200 mg/day, and this level is identified as the OSL.



Thus, CoQ10 functions in every cell of the body to synthesize energy.



Antioxidant function of CoQ10



A 2002 study in 80 Parkinson's disease patients found 1200 mg/day reduced the progression by 44%.[74][75] A phase III trial of 1200 mg/d and 2400 mg/d ran until August 2011. This study was terminated and the summary concluded: "The investigational drug is unlikely to demonstrate efficacy over placebo for this indication. However, no safety issues were discovered."[76]


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